SS-31 (50mg)
SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets the inner mitochondrial membrane via binding to cardiolipin, investigated extensively in research for mitochondrial dysfunction in cardiac, renal, and neurodegenerative models.
About SS-31
SS-31 (also known as Elamipretide or MTP-131) is a small synthetic tetrapeptide developed to selectively accumulate in the inner mitochondrial membrane. Its design enables binding to cardiolipin — a phospholipid unique to the inner mitochondrial membrane that is essential for electron transport chain function. SS-31 has been extensively investigated across multiple disease models involving mitochondrial dysfunction.
Mechanism in Research Literature
Research on SS-31 has documented:
- Selective concentration in the inner mitochondrial membrane (orders of magnitude higher than cytoplasm)
- Binding to and stabilization of cardiolipin against oxidative damage
- Preservation of electron transport chain function under oxidative stress
- Reduction of reactive oxygen species generation by stressed mitochondria
- Effects on ATP production in mitochondrial dysfunction models
- Activity in high-energy-demand tissues (cardiac, renal, neuronal, muscle)
Research Context
SS-31 has been investigated in studies exploring:
- Cardiac mitochondrial dysfunction and heart failure research
- Renal ischemia-reperfusion injury models
- Neurodegenerative disease research (Alzheimer’s, Parkinson’s models)
- Mitochondrial aging across high-energy tissues
- Cardiolipin biology and inner-membrane stabilization
Related Research Peptides
SS-31 appears in literature alongside other mitochondrial- and longevity-research compounds (MOTS-c, NAD+, Epithalon, NA Epithalon) and antioxidant research (Glutathione).
