KPV (10mg)
KPV is a tripeptide (Lysine-Proline-Valine) corresponding to the C-terminal end of α-melanocyte-stimulating hormone (α-MSH), investigated in research for anti-inflammatory and antimicrobial activity.
About KPV
KPV is a small tripeptide composed of lysine, proline, and valine — the C-terminal three amino acids of α-melanocyte-stimulating hormone (α-MSH). Research has explored whether this short fragment retains the anti-inflammatory and antimicrobial activity of the parent hormone while shedding the pigmentation effects associated with melanocortin-1 receptor activation.
Mechanism in Research Literature
Research on KPV has documented:
- Binding to melanocortin receptors with anti-inflammatory effect
- Inhibition of NF-kB activation in inflammatory signaling
- Suppression of pro-inflammatory cytokine production (TNF-α, IL-1, IL-6)
- Direct antimicrobial activity against several bacterial and fungal species in research models
- Effects observed in gut inflammation models and skin inflammation research
Research Context
KPV has been investigated in studies exploring:
- Inflammatory bowel disease research models
- Skin inflammation and barrier function
- Antimicrobial peptide pharmacology
- Melanocortin receptor selectivity research
- Combined anti-inflammatory and antimicrobial mechanism investigation
Related Research Peptides
KPV appears in literature alongside other anti-inflammatory and tissue-repair research peptides (BPC-157, TB-500, VIP, Thymosin Alpha-1) and as a component of the KLOW research blend.
