AOD-9604 (5mg)
AOD-9604 is a synthetic fragment of human growth hormone (residues 176-191) investigated in research for its effects on lipid metabolism, with observed selectivity for adipocyte function over the broader GH receptor activity.
About AOD-9604
AOD-9604 (Anti-Obesity Drug-9604) is a synthetic peptide comprising the C-terminal 16 amino acids of human growth hormone (residues 176-191), with a tyrosine added at the N-terminus for stability. Research has focused on its lipolytic activity and the observation that it appears to retain fat-metabolism signaling associated with full-length GH while showing minimal activity at the growth hormone receptor.
Mechanism in Research Literature
Research on AOD-9604 has explored its action on adipocyte (fat cell) metabolism. Observed mechanisms in the literature include:
- Stimulation of lipolysis (breakdown of stored triglycerides) in adipose tissue
- Inhibition of lipogenesis (formation of new triglycerides)
- Minimal interaction with the growth hormone receptor
- No observed elevation of IGF-1 levels in research models
- No reported effects on glucose handling or insulin sensitivity in published studies
Research Context
AOD-9604 has been investigated in studies exploring:
- Adipose tissue metabolism and lipolytic pathways
- Differential signaling between full-length GH and its C-terminal fragments
- Metabolic peptide research as it relates to body composition models
- Comparative pharmacology against other GH-derived peptides
Related Research Peptides
AOD-9604 appears in research literature alongside other compounds studied for lipid metabolism (Tesamorelin, 5-Amino-1MQ) and GH-pathway peptides (CJC-1295, Ipamorelin).
For research and educational use only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
