5-Amino-1MQ (50mg)
5-Amino-1MQ is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) investigated in research for its effects on adipocyte metabolism and cellular NAD⁺ regulation.
About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in white adipose tissue and elevated in research models of obesity and metabolic dysfunction. Research interest has focused on the link between NNMT activity, intracellular NAD⁺ levels, and adipocyte metabolism.
Mechanism in Research Literature
NNMT methylates nicotinamide using S-adenosylmethionine (SAM), consuming substrates required for NAD⁺ biosynthesis. Research on 5-Amino-1MQ has explored NNMT inhibition and its downstream effects:
- Reduced consumption of nicotinamide and SAM
- Elevated intracellular NAD⁺ levels in adipocytes
- Observed reduction of adipocyte size in research models
- Altered expression of genes related to lipid storage and energy metabolism
- Effects on cellular methylation balance via SAM preservation
Research Context
5-Amino-1MQ has been investigated in studies exploring:
- Adipocyte hypertrophy and fat tissue expansion in metabolic dysfunction models
- NAD⁺ pathway regulation and the link between methylation and metabolism
- NNMT as a metabolic target distinct from receptor-based mechanisms
- Comparative pharmacology against other NAD⁺-restoring compounds
Related Research Peptides
5-Amino-1MQ appears in research literature alongside other NAD⁺-pathway compounds (such as NAD+ itself), mitochondrial peptides (MOTS-c, SS-31), and compounds investigated for adipose tissue metabolism (AOD-9604, Tesamorelin).
